7-methyl carbazole-4-one undergoes condensation reactions with semicarbazide hydrochloride, thiosemicarbazide, 2-aminothiazole and 2-aminobenzthiazole to give bidentate N,O and N,S donor (E)-N-(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-ylidene)thiazole-2-amine [MCT], (E)-N-(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-ylidene)benzthiazole-2-amine [MCB], (E)-2-(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-ylidene)hydrazine carbothioamide [MCCT], (E)-2-(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-ylidene)hydrazine carboxamide [MCCX] Schiff base ligands. These bidentate Schiff bases formed complexes by reacting with cadmium salt. Structures of these Schiff bases and their complexes have been determined on the basis of their physical, analytical and spectral data. The screening result of these compounds indicates that they possess excellent antibacterial as well as antifungal activity against tested pathogenic organisms E. coli, B. Subtilis, A. niger and A. Flavus. However in comparison their metal chelates have been shown to possess more antibacterial and antifungal activities than the uncomplexed Schiff bases.
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